j********r
发帖数: 156 | 1 accumulates in M phase, and is rapidly degraded upon entering G1 phase. 大家猜
猜这个蛋白是干啥的。It might be subject to the transcriptional regulation by
E2F
family proteins.
貌似这个蛋白对M phase exit起作用。Not sure where to pursue next, 盼大牛指点
一下！ |
O******e
发帖数: 4845 | 2 See what happens after you knock it down by RNAi
家猜
by
【在 j********r 的大作中提到】
: accumulates in M phase, and is rapidly degraded upon entering G1 phase. 大家猜
: 猜这个蛋白是干啥的。It might be subject to the transcriptional regulation by
: E2F
: family proteins.
: 貌似这个蛋白对M phase exit起作用。Not sure where to pursue next, 盼大牛指点
: 一下！
|
j********r
发帖数: 156 | 3 Knocking-down causes modest accumulation of cells at G2/M phase, and obvious
cell death. Oncogene， 你说这个蛋白是干啥的？多谢了， |
O******e
发帖数: 4845 | 4 首先去确定不是off-target effects。
然后看看那些个caspases的变化，是不是可以得到些线索。
可能性太多了
obvious
【在 j********r 的大作中提到】
: Knocking-down causes modest accumulation of cells at G2/M phase, and obvious
: cell death. Oncogene， 你说这个蛋白是干啥的？多谢了，
|
