z*h
发帖数: 773 | 1 Science -- Could Wood Feed the World
http://news.sciencemag.org/sciencenow/2013/04/could-wood-feed-t
The main ingredient of wood, cellulose, is one of the most abundant organic
compounds on Earth and a dream source of renewable fuel. Now, bioengineers
suggest that it could feed the hungry as well. In a new study, researchers
have found a way to turn cellulose into starch, the most common carbohydrate
in the human diet.
Ethanol is today's most common biofuel used to power vehicles. It's
typically... 阅读全帖 |
|
L*********y
发帖数: 322 | 2
You might want to do more function-structural analysis of this transporter
to back up your data.
For example, within this transporter, can you identify the key amino acid
residues or protein domains that affect the compound binding? Second,
can you synthesize a fluorophore or radiation conjugated version of this
new compound you discovered? If yes, you should be able to test its
interaction with your transporter by IP.
Third, Can you do some in vivo experiments to support you in vitro findings... 阅读全帖 |
|
d****i
发帖数: 2346 | 3 现在实验室里面的4C和-20C冰箱都是frost free的，储存在里面的东西每天经受着反复
冻融，这种反复冻融对RNA, DNA, medium, compound powder和compound stock
solution那一个影响最大？
目前让老板把这些冰箱都换掉不现实。。。。。现在有一个实验，同一个公司的
compound隔壁实验室做的出来我们就做不出来，绞尽脑汁不知道什么原因。。。。。。
。 |
|
s******c
发帖数: 331 | 4 这个就是太乐观的看法，作为一个搞结构的，稍微跟pharmacology沾点边的半外行，说
一些粗浅的理解。
首先，药物分子水平的机理太复杂，结构能看的就是，药物小分子和一种蛋白在某个位
点上的相互作用有哪些。就这些信息，仍然受很多因素的影响，很多时候都不是致命一
击，比如小分子affinity低，占有率低，或结构分辨率低，就会有很多问题，如果小分
子太小，fit电子密度可能性有很多种，或小分子太大，不是所有的部分都有清晰的密
度，这个时候就很难讲，在这上面出错的结构有很多。结构不能揭示的药物分子机理就
太多了，药物怎么代谢的（往往很多药物代谢底物才是真正结合靶点的小分子），怎么
进细胞或怎么上膜，即便是跟靶蛋白，小分子进入和离开靶蛋白的kinetics，on rate
和off rate，进入binding site的整个process（first binding site，secondary
binding site etc）都是静态结构不能看到的，而这些信息很多时候才是重要的，比如
对于很多药物，其进入binding site的通道或过程往往决定其特异性，而不是结构看到
的bind... 阅读全帖 |
|
m*********D
发帖数: 1727 | 5 谢谢！刚找了一遍pUC18/19，都十多年没用过了，哪里找得到！还好，试验室好像有一
个自己作的cloning vector,估计是在pUC上多加了几个克隆酶位点，大小差不多（less
than 3kb)，应该可以用。
好，genomic region全sequence了，有两个SNP, 在intron region,也就是作HDR的ARMS
上，对整个设计没有影响。primers全送出去了，就等克隆一类。今天把几个要用的酶
买回来就可以过节了。
搞的这么复杂主要是想test我们自己筛选出来的compound。compound在WT上肯定每问题
，这些mutant是现有drug-resistant的病人里找出来的，所以，怀疑是drug-resistant
的机理之一。我要能建好一个细胞系，两个拷贝都突变的话，就把我们的compound往前
推进一大步。一个copy突变，一个不突变，该是病人的真实情况，但两个拷贝之间的表
达不清楚，所以，我要运气好，两个都变成mutant，那就太好了。 |
|
m*********D
发帖数: 1727 | 6 真的呀？我们这里没有NIH资助的HTS center,但学校自己搞了一个，礼拜三我还和那个
director聊天呢。生意不多，但总断断续续有教授们过来筛。library不大，就
Cambridge的那个15万个compound,加上这里的一个教授自己收集的一万个compound和
NIH的一个structure-diversified library,大约两千compound吧。后面两个，我当年
作assay development的时候，手筛了一遍。
那太可惜了。NIH自己好像有一个，任何NIH资助的research，好像筛选是free的，就是
自己develop HTS assay，把材料给他们。但好像他们的数据马上公开，所以，有人不
愿意。 |
|
w*********o
发帖数: 3030 | 7 Big pharma works with academic too. They provide funding for some basic
research (something like funding a postdoc position or project by project
based) for target identification or direct collaboration on a compound if
they think the compound is interesting enough. The key is to know the where
the chances are. Your boss might need to go to try to find some connections
in industry. It might also need proposal (the first case) or tough
negotiation (the second case). But the proposal is much less ... 阅读全帖 |
|
m*********D
发帖数: 1727 | 8 我们是从理论作到药物筛选的，对Mechanism of Action还算比较深入。当然，对每个
具体的compound，总是难说清的。作药的方面，现在有一个三年的funding，一年已经
过去了，加上funding不大，今年过了，明年还有没有钱就难讲了。这作起animal试验
就是烧钱啊。没renew上的其实是作mechanism方面的。
你说的这个流程，和我以前筛的一个compound有相似的地方。当时potency不够，就向
找chemist优化，拿了五年的钱，现在布什用完了么。这个compound因potency不错，合
作的chemist说没必要了。现在就看在身体里的稳定性如何，这个马上要作了。比较细
胞和老鼠的用量，在身体里的稳定性可能会有问题，但不会太大，毕竟在老鼠上的用量
足够作药，但从老鼠到人的跳跃还是未知数。
谢谢指点！
more
industry |
|
m*********D
发帖数: 1727 | 9 你说我们现在的compound?我们搞生物的没本事作合成，只能找市场上现存的可以买来
的strucuture-related compound来试试。从学术角度看（我们找的chemist也是学术界
的。他们导师有compound在临床二期了。），我们这样的potency很高了，再合成就没
有必要了。但你们industry不一样，连backbone都可能换的，好钻patent的空子，自然
比我们要强多了。
还在申请patent阶段，能不能拿到还不知道呢。所以，还没有大的VC有兴趣。另外，我
们的抗药性细胞的结果也是很关键的一步，不然，现存的药已经有了，我们不能进一步
，也不会有VC干兴趣的。当然，我们因为知道一些MOA,对抗药性癌细胞还是比较
confident。但总是希望看到实在的结果后才能说。所以，离卖还有很远的路要走。
optimization和可能看动物代谢试验后决定是不是有优化的必要。
unless |
|
m*********D
发帖数: 1727 | 10 希望是好事多磨。刚完成characterization我的CRISPR mutants,看我们的compound是
不是还能杀死这些drug-resistant的癌细胞。下个礼拜就知道大概了。要能，就往前推
进了一步；不能，也对compound的机理也多了解了一步，知道compound适合的人群了。
谢谢！周末愉快！ |
|
m*********D
发帖数: 1727 | 11 生物千老的命运很大程度上是不能自己掌控的。这种靠老板经费来维持的职位，任何一
个环节出问题，工作就没了。本人经历过或看到过的，包括老板经费没续上而丢工作的
；老板tenure没拿到要搬迁而千老因家庭原因走不了而失业的；新人取代旧人的；和老
板关系紧张而被赶走的。。。生物人多，尤其有一个Ph.D. title后，工作是僧多粥少
，千老一但失业，再找机会就少了很多，往往是愿意低就都难。毕竟生物技术是日新月
异，旧人要和新人争抢饭碗，有太多的不利和短处。
本人土博，千老20余年，除了其中两年因老板没有经费而在公司里干了两年外，其它时
间都一直在象牙塔里。除了老板不错本人的运气不算差之外，还有一个重要的因素就是
我从来都把实验室的经费（申请）放在个人兴趣/利益的前面。今年是我在这个系统里
的第20个年头，上个月老板的proposal又以top 5%亮丽成绩胜出，如果还能搞一个小的
grant,我下面五年的工作就基本能保证了。这20余年千老生涯算有惊有险，一路走来，
感慨颇多。
最重要的是关系网。我在美国朋友很多，本人在朋友中也一向是以诚实/靠得住出名。
所以，很多转折关头往往是推荐信和open... 阅读全帖 |
|
m*********D
发帖数: 1727 | 12 今天一进办公室，老板就来找我：今天我不得不早点来。九点有个电话会议，和一家公
司，还有学校的律师一起讨论你用CRISPR技术作的细胞lines。公司对你的这个细胞
lines有兴趣，主要是用来作乳腺癌的药物筛选。。。
其实已经转让给另一个合作实验室了。当然，这个实验室是在学术界的，也是作乳腺癌
的药物筛选。自从三年前高通量测序被用来检测抗药性乳腺癌病人的癌细胞里基因突变
的情况，找到了约三分之一的病人带雌激素受体（ER)的基因突变后，乳腺癌这块的药
物筛选全往找能对付mutants的药物方向转变了。所以，我用CRISPR技术把这些突变引
进到ER基因上，并且拿到ER基因的两个拷贝都突变的细胞lines。这个在药物筛选上就
很有用了--这家拿我细胞lines的实验室就给我说：太方便了！要看ER蛋白表达变化，
我们就不用担心ER抗体是不是能区分wild-type还是mutants了。compound有效也就知道
一定是针对mutants的。他们动作很快，才拿了我的细胞lines几个月，上礼拜就通知我
文章已经送审了。我虽然是十几个作者中最不重要的一个，但看到自己作的东西有用，
还是感觉不错... 阅读全帖 |
|
S**I
发帖数: 15689 | 13 Introduction
Chapter 1 Solutions
Chapter 2 Halogens
Chapter 3 Structure of Matter
Chapter 4 Chemical Reaction Rate and Chemical Equilibrium
Chapter 5 Electrolytes
Chapter 6 Coordination Compounds
Chapter 7 Oxidation and Reduction Reactions
Chapter 8 Oxygen and Nitrogen Families
Chapter 9 Introduction to Organic Compounds
Chapter 10 Aliphatic Hydrocarbons (guess this is what you mean)
Chapter 11 Aromatic Hydrocarbons (guess this is what you mean)
Chapter 12 Halocarbon Compounds
Chapter 13 Alcohol |
|
P***e
发帖数: 804 | 14 Both of the two categories of compounds contribute to wine aroma. In
general sulfur-containing compounds are defects. Some sulfur compounds
are good at low concentrations. Monoterpenes gives floral aromas that
are important in Muscato and Riesling. |
|
m******g
发帖数: 39 | 15 版上大牛,救命啊. 我想用FDAA (Marfey reagent) derivitize 我的amino(NH2)-ester
-salt(HCl) 手性对应体(几乎没有UV吸收). 我的compound溶在含过量TEA的DCM中. 这
样TEA先中和掉compound中的HCl,NH3(+)Cl(-)-R-COOCH3 变成NH2-R-COOCH3 然后和4%
的FDAA in ACN 反应. FDAA过量一些. 反应在50C, 进行2小时. 上HPLC column, 结果
居然没看见我的compound的peak. 看起来就像没反应, FDAA到像是falling apart了.
大牛看看我的反应条件是不是有问题啊? |
|
w**q
发帖数: 43 | 16 这哥们还是不错的.是第一个合成physostigmine的。当年“挑战”罗伯特·罗宾逊堪称
经典。这也是科学之美。他受到过不公正待遇。去世前两年当选为院士。
“In a series of ten beautiful papers Robinson and his co-workers have
described syntheses of compounds which they call “d,Z-eserethole” and “d,
Z-esermethole.” Their “d,Z-eserethole” is not the compound (XII)
described in this communication as d,Z-eserethole, and the constitution of
which can hardly be questioned. We believe that the English authors are in
error, that the compound they describe as d,leserethole is not... 阅读全帖 |
|
c*****a
发帖数: 845 | 17 某知名跨国制药企业上海研发中心急聘medicinal chemistry Director.
这个岗位寻访了2年了，一直没有特别合适的人，欢迎大家有兴趣的来咨询。
Responsibilities
Ø Initiate and direct design and synthesis of bioactive small molecules
for drug discovery programs
Ø Direct involvement of experiments in the chemistry laboratory
Ø Progress medicinal chemistry program through in-depth structural
activity/property relationship analysis, and structural-guided drug design
Ø Execute hypothesis driven compound design and synthesis
Ø Monitor ti... 阅读全帖 |
|
s***l
发帖数: 2236 | 18 I find this could be an interesting topic to talk about.
The competition between Si and other materials, particularly
III-V compounds is really interesting.
When III-V compounds first come to people's mind, lots of them
think they will substitute Si since their characteristics
are much better than Si in many ways, such as high freq
response, high gain, low loss, etc.
The most important drawback of III-V compounds is fabrication.
And that's just the advantage of Si based device.
So with time goes |
|
K**********n
发帖数: 1197 | 19 学术界珍稀有限的原版外文资料，
Remote Mind Control Technology
Reprinted from SECRET AND SUPPRESSED: BANNED IDEAS AND HIDDEN
HISTORY, edited by Jim Keith, $12.95, available from
1-800-680-INET.
There had been an ongoing controversy over health effects of electromagnetic
fields (EMF) for years (e.g., extremely low frequency radiation and the
Navy's Project Seafarer; emissions of high power lines and video display
terminals; radar and other military and industrial sources of radio
frequencies and micr... 阅读全帖 |
|
x*y
发帖数: 32 | 20 Postdoctoral Fellowships
Postdoctoral positions are available to explore metabolic diversity
among bacteria that degrade natural and synthetic organic compounds. The
emphasis is on discovery of novel enzymes and catabolic pathways using
microbial physiology, genomics, and molecular biology. A second position
will emphasize biodegradation kinetics and mechanisms in natural soils
and sediments. The laboratory is well equipped with analytical
instruments and all the facilities needed for cell culti... 阅读全帖 |
|
s****e
发帖数: 2934 | 21 Thank you very much for your comprehensive information!
I need to measure electric properties of my compound, so a thin layer of
PMMA is not ok for me. My compound is also a silicone compound, which is a
nonpolar. I have tried xylene, toluene, hexane, THF, ether. For xylene and
toluene, only 50%-40% can fully wet the wafer before I spin the spinner. So
all the other concentration can not fully wet the surface, everything is
gone when spin for 2mins at 1500RPM. For the 40% one, crystalline is big |
|
w****l
发帖数: 122 | 22 以前无意中看过一个drug development department做的一个compound的research.
就是按照indication 来， 其他公司的竞争compound 的机理，clinical 到哪一
步了， patent expirate data, which company, 等等。
从而make business decision 关于自己公司的compound怎么往下做.
可我不及得这样的报告是的出处了。 是哪个公司提供这样的调查报告吗？？？
thanks! |
|
n*********b
发帖数: 140 | 23 You may apply for a patent with very narrow claims. When the compound is
commercialized, your company needs to cross license many other patents
especially those covering the same or similar compounds. The worst case is
that the compound of similar activity is already being developed by your
competitor with patent protection. |
|
j*******1
发帖数: 266 | 24 “我个人不认为西医或者FDA的办法就是全对，但是你所想要推进的东西在目前的技术
手段下，我个人是绝对不赞成的。”
我个人认为西医或者FDA的办法是对的，但它有本身的限制。光学显微镜看到细菌的结
构是对的，但它看不到病毒的结构。什么是我所想要推进的东西在目前的技术手段？
Enoxaparin 和Pentosan Polysulfate sodium 是每个的通过FDA三期试验的药物，
Enoxaparin 是low-molecular-weight heparin，它们的分子量不同，但还是heparin (
C26H40N2O36S5)n，它的话性成分是(C26H40N2O36S5)n
http://en.wikipedia.org/wiki/Enoxaparin_sodium
Pentosan Polysulfate sodium 性质类似。
http://en.wikipedia.org/wiki/Pentosan_polysulfate
它们都是polymer, 分子量不同，基本结构一样，和我说谈到不同结构的compounds 是
不同的概念，它们能治我所说的第三类疾病？
“com... 阅读全帖 |
|
j*******1
发帖数: 266 | 25 FDA has no guidelines against combo, however due to high cost of the trials,
no company can afford to do a trial with combo.
If it takes $1.5 billions to have one compound drug into market, how much
does it take to have three compounds drug into market? Which company can
afford that kind of risk?
Do you have any example that a drug company test two more more unknown
compounds in the same trial?
FDA
. |
|
f****6
发帖数: 4472 | 26 不能提indication，不能提Compound#，不能给protein sequence，不能给peptide
sequence，可以讲methodology
我觉得比较敏感的东西都不能放到slides上，除了讲methodology，你还可以说，之前
我做过一个compound，这个compound如何。。。 |
|
g**********n
发帖数: 4 | 27 工作描述如下， 本人的背景跟这个位置非常match，简历基本cover所有discription，
已经在线投简历，还请有关前辈多多指点，帮忙再push一下简历给Hiring Manager就太
好了！先谢了.
（在线简历是个德文网站，还要browser翻译成英文，最离谱的是还提示要用“原始语
言”投简历，以便recruiter筛选，算是奇葩经历了）
Job Description A health care company with global reach. A product pipeline
filled to the brim. A team committed to scientific advancement. Think what's
possible. Novartis and its associated companies are always looking for
talented employees globally. We are engaged in advance preparation for
potential position openings.... 阅读全帖 |
|
c*****a
发帖数: 845 | 28 某知名跨国制药企业上海研发中心急聘medicinal chemistry Director/D
这个岗位寻访了2年了，一直没有特别合适的人，欢迎大家有兴趣的来咨询。
Responsibilities
Ø Initiate and direct design and synthesis of bioactive small molecules
for drug discovery programs
Ø Direct involvement of experiments in the chemistry laboratory
Ø Progress medicinal chemistry program through in-depth structural
activity/property relationship analysis, and structural-guided drug design
Ø Execute hypothesis driven compound design and synthesis
Ø Monitor t... 阅读全帖 |
|
b**o
发帖数: 5769 | 29 The sponsor of National student pharmacist compounding competition is
Medisca.
PCCA is not the only company there.
Yes, got to watch FDA for compounding. They consider compounded drugs as new
drugs. |
|
m****p
发帖数: 404 | 30 原文
http://forums.studentdoctor.net/showthread.php?t=884279
念药学院的学长学姐有什么评论么
德州 加州 pharmacy school 一家一家的开 2015-2020 铁定会过饱和了吧
最后几段是讲his family 自己开店30年的经验/挫折
还有文中提到的 MTM 是什么缩写?
1st -- Before you jump on me, understand this: I am only speaking about what
I know from extensive analysis of the California market (maybe some of this
will translate into other states but again this is for California people
primarily). If you attend, UCSF, USC, Western, UCSD, etc this job market
post is for you.
2nd -- Feel... 阅读全帖 |
|
b******8
发帖数: 1251 | 31 我，既没有在学校当任何leadership,也没有在外面上班，同学认识不到1半，属于学业
一般，人缘也一般的那种，commute,每天下课就不见人影了。
2013年：
- 学业结束，3.5 GPA，有什么用呀，我又不申请residency.
- NCPA business plan得了第二名，总算有点可以写在resume上的
- APPE开始：
1. specialty pharmacy: 这个我比较喜欢，工作轻松，还被病人感谢，有个specialty
,病人都是癌症呀之类的重病人，比较尊重人，就是工作太少，我们这地要是没人挪窝
的话，估计不胡有opening
2. am care,遇到了一个bitch preceptor,虽然最后人还是可以的，不过这个rotation
一直我就没有放松过，主要是warfarin clinic, MTM, 说实话，坐下来，我真的替那些
warfarin clinic的pharmacists惋惜，他们都是residency trained的，都能做更好的
事，warfarin clinic给病人check INR感觉就是护士的事，每天每人打10页的电话，... 阅读全帖 |
|
b******8
发帖数: 1251 | 32 我，既没有在学校当任何leadership,也没有在外面上班，同学认识不到1半，属于学业
一般，人缘也一般的那种，commute,每天下课就不见人影了。
2013年：
- 学业结束，3.5 GPA，有什么用呀，我又不申请residency.
- NCPA business plan得了第二名，总算有点可以写在resume上的
- APPE开始：
1. specialty pharmacy: 这个我比较喜欢，工作轻松，还被病人感谢，有个specialty
,病人都是癌症呀之类的重病人，比较尊重人，就是工作太少，我们这地要是没人挪窝
的话，估计不胡有opening
2. am care,遇到了一个bitch preceptor,虽然最后人还是可以的，不过这个rotation
一直我就没有放松过，主要是warfarin clinic, MTM, 说实话，坐下来，我真的替那些
warfarin clinic的pharmacists惋惜，他们都是residency trained的，都能做更好的
事，warfarin clinic给病人check INR感觉就是护士的事，每天每人打10页的电话，... 阅读全帖 |
|
s**********i
发帖数: 711 | 33
you probably can use a gel filtration column if the compound is
water soluable -- balance the colmn with soluable bromide compound,
run your compound through it, ClO4- should be left behind.
find companies make column resins, such as pharmacia, superco, biorad...
call their technical support and ask what you should use. |
|
s*k
发帖数: 144 | 34 【 以下文字转载自 ChinaNews 讨论区,原文如下 】
发信人: sdk (sdk), 信区: ChinaNews
标 题: Re: Columbia Radiation Incident: Asking for help.
发信站: The unknown SPACE (Tue Mar 14 20:16:58 2000) WWW-POST
Here is an technical outsider's suggesstion:
First, could you two make clear what chemical compound of P32?
Different compounds have significant differences on chemical
and physical properties. Besides the chemcal compound also can
provide a hint of where it origin and even how it landed in you
badroom.
Second, could you t |
|
j*******g
发帖数: 2140 | 35 3个animal,两组treatment,veh and compound, 第一天每个animal上都分别放了veh,
第二天是wash time; 第3天每个animal上放compound. 然后有每隔两个小时测的数据.
其中还有不少是missing的. 现在要看,veh 和 compound表现同不同.
问题时,只有3个animal阿..
请大家看看该怎么做..多谢. |
|
|
d**********0
发帖数: 13081 | 37 http://en.wikipedia.org/wiki/Organoarsenic_chemistry
Organoarsenic chemistry
From Wikipedia, the free encyclopedia
Organoarsenic chemistry is the chemistry of compounds containing a chemical
bond between arsenic and carbon. A few organoarsenic compounds, also called
"organoarsenicals," are produced industrially with uses as insecticides,
herbicides, and fungicides. In general these applications are declining in
step with growing concerns about their impact on the environment and human
health. Th... 阅读全帖 |
|
|
s***y
发帖数: 1130 | 39 昨天去上了第二次compound bow的课
就像教练说的，第一次课重点是纠正姿势和习惯，这一次课开始向准确度方面倾斜
上次被compound bow 3磅多的重量郁闷到了，回家后针对左臂平举做了一些锻炼。这次
再来，发现颇有成效，持弓更加稳定，弓弦打小臂的状况也有所好转，不过练习到后半
段还是左臂先开始疲劳，右手拉25磅的弦倒是完全无压力。
上课的时候，教练发现我是“双眼瞄准”，特地叫我闭左眼试试（右撇子），结果效果
还不如两只眼都睁开。我觉得是练习弓上没有瞄准器的缘故，不然“两点一线”，还是
闭一只眼效果更好
最后举不动compound，就和教练提议玩玩轻一点的recurve。发现recurve果然要难操控
很多，虽然重量轻不少。
目前自己的最大问题，还是松弦的手势不对，以及出箭瞬间的form会变形。在教练那里
看到有个练习松弦的小沙包，不知道哪里有卖的 |
|
p****y
发帖数: 23737 | 40 科学家最近发现西瓜中富含扩张血管的化合物—— L-瓜氨酸，可以减少心肌梗塞和中
风的危险。研究发现每日喝一定量的西瓜汁可以使高血压病人的血压下降[注]。
英国有160万人患有高血压，使心梗和中风的死亡率双倍地增加。英国人每年死于心梗
和中风者达6万以上。
一氧化氮是能使血管内皮扩张的重要物质，西瓜种的L-瓜氨酸可以使血液中的一氧化氮
含量明显增加。美国科学家给患高血压的自愿者每日6克从西瓜种提取出的L-瓜氨酸。6
星期后，9名受试者的血压均有下降，而且无副作用。但是如果是吃西瓜，大约一个半
西瓜才可达到这种治疗剂量。
佛罗里达州立大学的Arturo Figueroa博士说：这项研究说明保健食品有扩血管作用，
有一些食物可以防止高血压的发生，从而避免心梗和中风。虽然研究刚刚开始，结果令
人鼓舞，为今后在更多的人群中研究打下了坚实的基础。
研究人员之一Bahram Arjmandi教授说：所谓保健食品是指那些能促进健康、或防止疾
病、或多或少含有内在营养成分的食物。
科学家指出桔黄色的西瓜中的L-瓜氨酸含量高于红西瓜。两种西瓜均富含维生素A、维
生素B6、维生素C和纤维。西瓜中还含有钾元... 阅读全帖 |
|
p****y
发帖数: 23737 | 41 http://www.vegetarian-nutrition.info/updates/vegetarian_diets_health_benefits.php
Recently, there has been a renewed interest in vegetarian diets. Today there
are countless books, cookbooks, and magazine articles promoting vegetarian
diets and providing guidance for those who wish to follow a meatless diet. A
Short Historical Perspective on Vegetarian Diets
In the past, many viewed vegetarianism as strange and faddish but
appropriately planned vegetarian diets are now recognized by many, includi... 阅读全帖 |
|
p****y
发帖数: 23737 | 42 http://article.yeeyan.org/view/161346/117054
清污于2010-07-12 21:45:23翻译
化肥的催长降低了水果的吸收土壤中养分的能力！专家提供九点建议，帮你获得更健康
的果蔬膳食。
这么多年以来，当我们近乎忠实地摄入水果和蔬菜时，一件奇怪的事情已经发生在这些
食品上。它们丢失了本该含有的营养。是真的，今天以传统方式生长的果蔬已经没有30
年前那般有益健康，它们只是变得更糟糕了。果蔬产品营养含量的下降早在10多年前就
被英国研究人员Anne-Marie Mayer博士首先提到，她观察到上世纪四十年代至八十年代
期间的20种英国生长农作物中矿物质含量在不断下降。
It's happening to crops in the United States, too. In 2004, Donald Davis,
PhD, a former researcher with the Biochemical Institute at the University of
Texas, Austin, led a team that analyzed 4... 阅读全帖 |
|
R**R
发帖数: 3318 | 43 【 以下文字转载自 Living 讨论区 】
发信人: RWKR (忍无可忍), 信区: Living
标 题: 小技巧：如何补墙洞。
发信站: BBS 未名空间站 (Wed Jan 20 14:39:27 2010, 美东)
1, 太小的：用牙膏。
2，大点儿洞：用putty knife 刮石膏（joint compound）, 干一天，打平，再用putty
knife 刮石膏,干一天，打平，刷漆。
3。 大洞：If big enough, screw new dry wall on the stuck and用putty knife 刮
石膏（joint compound）, 干一天，打平，再用putty knife 刮石膏,干一天，打平，
刷漆.
4。不大不小的洞：看图。塞一块木条到洞里，两边用螺丝固定。然后按洞大小补上新
的dry wall and 用putty knife 刮石膏（joint compound）, 干一天，打平，再用
putty knife 刮石膏,干一天，打平，刷漆 。若洞太小，手不方便，用绳记住木条。
注意：刮石膏至少两遍。石膏干了会收缩。
希望 |
|
w*******y
发帖数: 60932 | 44 Bigskytool.com has another "secret" coupon like the kc18dhl one last week to
save even more off the black friday prices on some miter saws. With these
coupon codes, they're like half off new prices. The c12fdh is a workhorse
miter saw!
They are factory recon and come with 1 year warranty. Two bad I don't need
three miter saws, but that'd be overdoing it in my garage just a bit .
Hitachi C10FCE2 10" Compound Miter Saw (Reconditioned)
$90.90 - $15 off coupon code MQEFYT = $75.90 (lowest price o... 阅读全帖 |
|
p**8
发帖数: 3883 | 45 看了一下，我们这里很多人看熊。但是，市场可能还很牛。如果秋月在的话，他一定会
提醒大家。希望他早日回来。
我上周也做空 RIMM 和 LCC，不过我昨天关了RIMM的空仓。由于他不在，我就胡说一下
：Barron在看牛，最好不要太看熊。
---- Barron's Cover：Enter the Bull ----
Barron's Cover | SATURDAY, FEBRUARY 11, 2012 Enter the Bull
By GENE EPSTEIN | MORE ARTICLES BY AUTHOR
Even by conservative measures, the Dow Jones Industrials could top 15,000 in
two years. Dow 17,000 is a 50-50 bet.
Article Comments (18)
Email Print Reprints smaller Larger
Based on cyclical patterns of market history, the odds are bette... 阅读全帖 |
|
X*****s
发帖数: 2767 | 46 【 以下文字转载自 HardTimeCall 俱乐部 】
发信人: XXLBass (大巴司机), 信区: HardTimeCall
标 题: What Happens When Bond Yields Are Lower Than the Inflation Rate?
发信站: BBS 未名空间站 (Sun Jul 8 23:30:01 2012, 美东)
By James Debevec Jul 06, 2012 11:45 am
Bond yields predict disinflation.
MINYANVILLE ORIGINAL Not long ago bond yields were lower than the inflation
rate. There were a number of articles commenting on the phenomenon. A common
piece of advice in many of these articles was to invest in commodities. The
basic logic wa... 阅读全帖 |
|
|
y*****l
发帖数: 5997 | 48 11/9 ER
https://research.scottrade.com/research/stocks/secfilings/drawFiling.asp?
docKey=137-000114420410058736-6IM04MBUCS1U6UGMGRICK8K85Q&docFormat=HTM&
formType=8-K/A
Explanatory Note:
On July 7, 2010, China Green Agriculture, Inc. (the “Company”) filed a
Current Report on Form 8-K (the “Report”) with the Securities and Exchange
Commission (the “Commission”), with respect to its acquisition of Beijing
Gufeng Chemical Products Co., Ltd., a company organized under the laws of
the People’s Republ... 阅读全帖 |
|
y*****l
发帖数: 5997 | 49 T-DM1 Significantly Improved Progression-Free Survival in Randomized Phase
II Trial
3 hours 20 minutes ago - BIZ via Comtex
BusinessWireImmunoGen, Inc. (Nasdaq: IMGN), a biotechnology company that
develops targeted antibody-based anticancer products, today announced that
Roche has disclosed positive top-line results from the first randomized
trial assessing trastuzumab emtansine (T-DM1, previously known as
trastuzumab-DM1) in HER2-positive metastatic breast cancer (MBC). T-DM1
consists of Immuno... 阅读全帖 |
|
h*h
发帖数: 27852 | 50 感觉很可能。卡达菲是疯狗
Witnesses describe violence, chaos in Libyan cities
By the CNN Wire Staff
February 21, 2011 1:25 p.m. EST
(CNN) -- While state TV bounced between scenes of serene concert footage and
orderly rallies in support of leader Moammar Gadhafi, eyewitnesses describe
a far different, far more chaotic Libya -- one with arms-toting mercenaries
, demonstrators ramming stolen tanks into a military base and masked men
firing guns and blasting pro-government tunes from their sport utility
vehicles... 阅读全帖 |
|
