p********r
发帖数: 1980 | 1 Nearly all of the transplants using privately banked cord blood have gone
to relatives with pre-existing conditions, not to the donors. So your
doctor's advice is not sound. In fact, why do people ask OB such
questions? They should ask doctors who really do stem cell transplants for
their opinion. |
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k****z
发帖数: 1863 | 2 http://en.wikipedia.org/wiki/Intestinal_neuronal_dysplasia
Intestinal neuronal dysplasia
From Wikipedia, the free encyclopedia
Intestinal neuronal dysplasia
Classification and external resources
OMIM 243180 601223
Intestinal neuronal dysplasia (or neuronal intestinal dysplasia or NID) is
an inherited disease of the intestine that affects one in 3000 children and
adults. The intestine uses peristalsis to push its contents toward the anus;
IND sufferers have a problem with the motor neurons tha... 阅读全帖 |
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发帖数: 1 | 3 J Heart Lung Transplant. 2014 Dec;33(12):1255-63. doi: 10.1016/j.healun.2014
.06.015. Epub 2014 Jun 26.
Early donor-specific antibodies in lung transplantation: risk factors and
impact on survival.
Ius F1, Sommer W2, Tudorache I1, Kühn C1, Avsar M1, Siemeni T1, Salman J1,
Hallensleben M3, Kieneke D3, Greer M4, Gottlieb J5, Haverich A2, Warnecke G6.
my Email: [email protected]/* */
Thank you very much. |
|
发帖数: 1 | 4 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
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g**a
发帖数: 2129 | 5 chemotherapy, radiation therapy and bone marrow transplantation, we don't
have much choice. transplantation is the best one. However it is always hard
to find a matching donor. Chemo is the 2nd best one and from my point of
view, should be the standard procedure until toxicity is high (which is rare
for well known drugs). There should be some good drugs for acute
lymphoblastic leukemia with big price tag. Radiation is the cheapest one. I
think you are talking about radiation therapy. |
|
R*******d
发帖数: 13640 | 6 【 以下文字转载自 Biology 讨论区 】
发信人: liujiatian (liujiatian), 信区: Biology
标 题: 2015年影响因子新出炉
发信站: BBS 未名空间站 (Thu Jun 18 23:51:32 2015, 美东)
Rank full journal title Total Cites IF
1 ca-a cancer journal for clinicians 18,594 115.84
2 new england journal of medicine 268,652 55.873
4 lancet 185,361 45.217
6 nature biotechnology 45,986 41.514
7 nature 617,363 41.456
12 nature materials 64,622 36.503
13 jama-journal of the american medical assoc... 阅读全帖 |
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c********p
发帖数: 322 | 7
agree
I dont have to get info from the hospital. Usually I give out info,lol.
Many years ago, I used to get organs from XXXXXXXXX several times for
transplant and I think I get 1st hand info about many things.what I can say
about the situation now is, 50W is not enough unless the family is powerful
or knows people. As I said, donor is a big big big problem and there are so
many people waiting for donor with money in hand.
Usually in a big city and in a 3A hospital, rarely you can find more than... 阅读全帖 |
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d***y
发帖数: 65 | 8 Call for donation
For the Kidney Transplant of Mr. YING Gao-Xiang
BSc94 and MSc99 of Environment Department, THU
People knowing Gao-Xiang will agree that he is a typical Tsinghua boy,
openhearted, problem-solving, loyal and good transcript. He also adapted the
typical path -- going abroad (US) after leaving Tsinghua. But it is so
shocking such catastrophe came to him. Kidney Transplant, no more words
needed. Let's do something to save our brother. Not only can our help save
his life, but also hi |
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s********e
发帖数: 1596 | 9 老了之后真的很难说啊，你就是存个两三百万养老，也很难保证轻松负担医疗费用吧。
到时候你的血汗钱都投进去之后，就觉得还不如一开始就没钱直接Medi-Cal呢。
再说个不公平的吧，很多医疗保险对transplant都有保费的上限，但是Medicaid没有。
我亲眼见过一些孩子因为是父母的普通保险，不得不保守治疗，没有做transplant，可
是如果父母没有买保险，家庭收入低，直接medicaid就没有这个问题！ |
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c****o
发帖数: 72 | 10 I just donated stem cell last November. (At this time, most donors will
donate stem cells instead of bone marrow).
The process was not painful. I had 3 (or 5?) injections to induce more stem
cells to be generated and released into my blood. After about 5 days, I
went through 5 hours collection. Basically I was sitting in a chair with
needles in my vein. I can not move much during the process (which was not
comfortable) but no pain for me. It has been over 6 months now. The
patient did the t... 阅读全帖 |
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c********m
发帖数: 571 | 11 Good news for Zhuzhu, maybe go to Nets?
Mourning forced to end NBA career, needs kidney transplant
November 24, 2003
EAST RUTHERFORD, New Jersey (Ticker) - Alonzo Mourning's NBA career is over.
The seven-time All-Star center will soon need a kidney transplant and will
no longer be able to play professional basketball, New Jersey Nets president
and general manager Rod Thorn announced on Monday morning.
"It is with great sadness that I make this announcement," Thorn said. "Alonzo
is a true champio |
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P**a
发帖数: 1267 | 12 还有这个Miracle-Gro本身土里面带了肥料的，所以前几个月不用施肥都可以长得很好,
以后就要重新施肥了。我一般在transplant之后施Miracle-Gro的transplant专用的
Quick Start，促使他们更快生新根。 |
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T*******m
发帖数: 27308 | 13 One square meter is big enough. Before you transplant the chives, make sure
you cut off some of the green leaves (at least half).
There is no need to transplant one chive plant a time. Just plant a small
bunch of them at the same time. Less time, higher yield.
Your own chives were planted way too sparse! You will probably need 3-4
square meters to harvest for one pound. |
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T*******m
发帖数: 27308 | 14 It may not be too late to transplant the seedlings into the ground. If I
were you, I would wet the small pots first then cut the containers with a
pair of scissors to avoid damage to the roots.
You may actually get one tomato or two if you don't transplant, but I guess
your tomato is not going to be bigger than the container itself. |
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s*********e
发帖数: 5245 | 15 希望最后那棵不死。怎么回事？红薯应该非常好种的。你的地是不是太干或太硬？
我在网上找了点信息。听说是要140天以上。菜种收到。一直没来得及致谢。昨晚找了
个ANTIQUE卡寄给了你，聊表谢意。
Planting
Sweet potatoes grow best in loose, sandy, well drained soil (well drained is
an absolute must for success). My strategy is to plant slips in raised
beds with a center ridge 10-12 inches higher than the surrounding area.
Each slip should be planted at a depth of approximately 2-3 inches (with the
leaves sticking above the ground). Within a row, you can plant successive
slips every 12 to 18... 阅读全帖 |
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m**e
发帖数: 27062 | 16 真
each group shared one dog, starting from skin transplantation
ending with kidney transplantation... |
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wh
发帖数: 141625 | 17 本篇发表于《Gettysburg Review》2003年夏季刊，李翊云从1978年一个反革命女孩的
死刑，写到她当时在幼儿园看到的反革命分子死刑前的游街，写到1991年她作为北大入
学生到河南信阳参加一年军训的经历。原文的排版更好看些：
http://www.gettysburgreview.com/selections/past_selections/deta
What Has That to Do with Me?
Yiyun Li
This story I am going to tell you, it is a true story.
The year was 1968. The girl was nineteen, the secretary of the Communist
Youth League for her class in a local high school in Hunan Province, China.
You probably don’t know much about Hunan, but I am sure you have heard... 阅读全帖 |
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j*j
发帖数: 5564 | 18 原作者Yann Martel在写了《Life of Pi》不久之后，又写了一部作品，
《We ate the children last》
可见他对吃人这个话题耿耿于怀，难以摆脱。这暗示他写《Life of Pi》的真实意图
中确实有写人吃人那一层意思，这层意思起码占50%吧。
说白了，写小说就是一个游戏，他故意要写得亦真亦幻，让那些经历不同信仰不同的读
者们对此作不同的解读。
-------------------------------------------------
We ate the children last
Yann Martel
The Guardian, Friday 16 July 2004
The first human trial was on Patient D, a 56-year-old male, single and
childless, who was suffering from colon cancer. He was a skeletal man with
white, bloodless skin who could no longer ... 阅读全帖 |
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s*****g
发帖数: 5159 | 19 感觉apple很悲情，就算Jobs看到AAPL卖300。
http://www.nytimes.com/2011/01/18/technology/18apple.html?_r=1&
Steven P. Jobs, the co-founder and chief executive of Apple Inc., is
taking a medical leave of absence, a year and a half after his return
from a liver transplant, the company said on Monday.
Mr. Jobs announced his leave in a letter to employees, saying he was
stepping aside “so I can focus on my health” but would continue to be
involved in major strategic decisions at the company.
“I love Apple so much ... 阅读全帖 |
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s****y
发帖数: 364 | 20 捐献角膜是义举和善事,我开始就同意,也没人否认.是否称得上神圣就是另一回事.但从
医学角度讨论一下是否有副作用也谈不上亵渎(可能除了在姚粉的眼里).就连神也是可
以自由讨论是否存在的不是吗.何况我的讨论不涉及姚贝娜, 只是针对医生的决定.
如果接受器官移植的人用药导致不排斥异体器官,也就会同样的允许了可能不小心移植
来的肿瘤细胞的繁殖.
角膜没有血管,但周围的边缘limbus是可能出现转移的癌症的.而手术中不太可能保证一
个潜在肿瘤细胞的污染都没有吧.
http://www.ncbi.nlm.nih.gov/pubmed/23928951
也发生过癌症患者去世后捐献角膜,后来病理检查剩余组织发现有癌变,导致接受角膜移
植的患者要接受再次角膜移植, 来替换掉第一次移植的有癌变可能的角膜.
http://www.ncbi.nlm.nih.gov/pubmed/18997546
这个文章的第一作者就是深圳的Yao, Xiaoming,很可能就是为姚贝娜摘除角膜的医生姚
晓明.他自己在文章里建议为避免移植角膜导致转移癌症到受者,移植角膜术前应做切片
病理检查. 所以希望他该做的检查都做了吧.接... 阅读全帖 |
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p********3
发帖数: 5750 | 21 50， 70， 71； 大家注意一下和这几篇文献相关的话题。 另外， 73-75我本人没有看，确实是谈的印度药材， 我在查阅参考文献的时候在搜索Chinese Medicine的时候， 显示有这些文献，我本人没有亲自看这些文献， 也许其中有讲中药的地方。不过这不影响我要表达的意思。
慢慢看：
INTRODUCTION — Plants have been used for medicinal purposes for thousands
of years. All major cultures including Native American, European, South
American, Asian, and African cultures have used botanicals for healing
purposes. As an example, saw palmetto was used for urinary symptoms in men
from Egypt in the 15th century BC [1]. Hippocrates documented... 阅读全帖 |
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M********s
发帖数: 24729 | 22 jennifer strohfus
Today at 11:27 AM
I traveled to Kyiv center of bone marrow transplant Ukraine) to see my
Cousin who is critically ill.she is been diagnosed with (Acute
Lymphoblastic Leukemia). I was advised that the only way She can survive is
by undergoing a BMT (Bone Marrow Transplant)
Please I really need your Financial assistance as this is a matter of life
and death.I hope you get back to me as soon as you get this mail
Thanks again
Jennifer |
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I****9
发帖数: 5245 | 23 【 以下文字转载自 MedicalCareer 讨论区 】
发信人: mczld531 (Unlimited Power), 信区: MedicalCareer
标 题: 实习在Boston 前篇
发信站: BBS 未名空间站 (Tue Mar 4 00:25:31 2014, 美东)
風は穏やかで日はうららか！
离毕业还有110天。
最近在Boston待了约五个月，圣诞回了趟上海，新年开始就一直在Boston复习CS和一些
extracurricular activity。2月中旬在Houston完成CS。考完還在休斯頓豐田中心邂逅
了火箭隊的教頭Kevin McHale.
在过去两年之中，完成了U Toronto, Baylor, Mount Sinai, Yale之后, 這次来到
Harvard Med。
2013年10月，同样是哈佛的附属医院，原来要去位于剑桥的Mount Auburn的ER急诊实习
，结果那边最近不接收学生，就去了Dana Farber/Brigham and Women’s Cancer
Center的骨髓移植科（Bone Marrow Transpla... 阅读全帖 |
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n******7
发帖数: 12463 | 24 最近一直在研究这个
癌症细胞可以调节自己周围的微环境，抑制免疫细胞
免疫疗法应该是癌症治疗的征途，最近的CAR-T牛逼的不像话了
In the CHOP trial, which is being conducted in collaboration with
researchers from the University of Pennsylvania, all signs of cancer
disappeared (a complete response) in 27 of the 30 patients treated in the
study, according to findings published October 16 in the New England Journal
of Medicine.
Nineteen of the 27 patients with complete responses have remained in
remission, the study authors reported, with 15 of these patients re... 阅读全帖 |
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H********g
发帖数: 43926 | 25 These natural barriers can be overcome in a laboratory, at least at first.
Such attempts typically result in a hybrid embryo which dies after a few
cell divisions.
For example, the egg's protective covering can be stripped off, allowing the
sperm of the other species access to the egg. Sperm can also be injected
directly into the egg. When this is done, fertilization occurs. The
resulting hybrid embryo is not viable, however. It typically goes through
one cell division, resulting in a two-cell e... 阅读全帖 |
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d**w
发帖数: 2474 | 26 poor jobs "Despite treatment for a neuroendocrine pancreatic tumor, first
diagnosed in 2004, and a liver transplant, the cancer likely has re-emerged,
Donahue said. In other patients who have liver transplants after
neuroendocrine pancreatic tumors, the median survival rate is typically
about two years."
"The company's stock fell about 5 percent in after-hours trading after the
news was announced, shortly after 3:40 p.m. PT (6:40 p.m. ET)."
No one is irreplaceable....
发现一个好笑的事情，请问你爱读卫生巾吗？。。。ＬＯＬ
... 阅读全帖 |
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b**********y
发帖数: 163 | 27 题目
pieces of dog parotid gland and of pancreas are transplanted under the skin of
the donor animal. after re-establishment of a circulation, ingestion of food
will result in secretion from:
a. parotid and pancreatic transplants.
b. the fragment of the parotid only.
c. the fragment of the pancreas only.
d. neither fragments.
which one? |
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n********k
发帖数: 2818 | 28 Yes,that's what he meant...and to me, there is a MUCh much bigger implication
beyond bone marrow transplanation,
which is for any transplantation work, no need for immunostuff because one
could in theory do a bone
marrow transplanation before other organs/stem cell transplantation... |
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n********k
发帖数: 2818 | 29 What an AMAZING woman! seriously!! I vote her to be a next Nobel laureate
and a first Chinese and it is a girl too....
http://english.cas.cn/accessory/twows4th/twowsaward/201006/t20100627_55793.html
Professor Fanyi Zeng was born in 1968. She received her B.A. in University
of California San Diego, CA, USA in 1991. In 2005, she got her Ph.D in
University of Pennsylvania, PA, USA.
Professor Zeng has led a research team that has made substantial and long-
lasting contributions to the developmental ... 阅读全帖 |
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a****d
发帖数: 1919 | 30 You are right, iPSCs hypo is still there. It's just such a crowded field now
and people are going nuts to compete for publishing.People from out lab
just found almost identical xx cell derived iPCSs results being published.
Those disease iPSCs models will continue to water on top journals for sure.
Along with that, reprogramming becomes hotter and hotter. For the next few
years, people still have to rely on TFs for reprogramming. Large small
molecular screening is on the way to replace those TFs... 阅读全帖 |
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a********k
发帖数: 2273 | 31 JCR Year and Edition: 2010 Science
Abbreviated Journal Title ISSN {2010} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2010} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 9801 94.262 70.216 8.667 18
3.8 0.04923 24.782
ACTA CRYSTALLOGR A 0108-7673 13944 54.333 24.717 0.629 70
6.2 0.04... 阅读全帖 |
|
|
s**u
发帖数: 9035 | 33 Dr. Samuel M Cohen(Chairman of Department of Pathology, UNMC) wrote a letter to "Toxicological Science" to criticize a misleading from Chengfeng Yang(Michigan State University)lab's a recent paper published in this journal, see below:
Reply to “Reversal and Prevention of Arsenic-Induced Human Bronchial
Epithelial Cell Malignant Transformation by MicroRNA-200b”
1. Samuel M. Cohen1
+ Author Affiliations
1. Department of Pathology and Microbiology, University of Nebraska
Medical Center, Omaha... 阅读全帖 |
|
z*t
发帖数: 863 | 34 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
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b****r
发帖数: 17995 | 35 "But with the second patient to receive the transplanted cells, Rosemary (
she declined to use her real name in order to protect her privacy), 51, a
graphic artist from Los Angeles, the researchers are more confident that her
visual improvements are related to the stem cell transplants."
看到没，就两个病人，一个表型根本无法解释，因为病人说她两只眼睛都视力提高，而
其实有个眼睛根本没有被治疗
黄斑色素变性的严重程度应该很大一部分靠病人主观判断（视力缺损范围和程度）。这
么主观的诊断标准和这么少的病例，我觉得根本不应该被报道出来，连本版这么专业的
地方都有这么多人觉得很promising，可见这篇文章对病人可能造成多大的误导
另外，光是MD的话，对这种类型的研究恐怕远不如PhD懂行。我两个学位都有，只是自... 阅读全帖 |
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m**********t
发帖数: 19 | 36 This drug is by far one of the most effective treatments of HL except for
stem cell transplantation. In the US, it is indicated for patients who have
failed in chemotherapy and stem cell transplantation (SCT). Not sure whether
your friends have already received SCT yet. In the clinical trial, 73% of
patients showed significant improvement and 40% had complete response.
Let your friend ask his physician. Usually, they can help you get this drug.
However, the only thing is this therapy is very exp... 阅读全帖 |
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o*******a
发帖数: 242 | 37 泥腿子也好，高中生也好。你最好还是听听，三人行也有我师。
In fighting for hepatitis B infection, the fucntion of cell mediated
immunity is important, but they are not as essential as you said. Instead,
HBsAb is the determining factor that eradicates virus from the body. That
you completely ignore the function of HBsAb is really shocking, and appears
like an un-educated paper reading machine.
You forget the common senses.
The common senses are:
1), HBsAb is REQUIRED to eradicate virus from the body.
In people with chornic h... 阅读全帖 |
|
o*******a
发帖数: 242 | 38 泥腿子也好，高中生也好。你最好还是听听，三人行也有我师。
In fighting for hepatitis B infection, the fucntion of cell mediated
immunity is important, but they are not as essential as you said. Instead,
HBsAb is the determining factor that eradicates virus from the body. That
you completely ignore the function of HBsAb is really shocking, and appears
like an un-educated paper reading machine.
You forget the common senses.
The common senses are:
1), HBsAb is REQUIRED to eradicate virus from the body.
In people with chornic h... 阅读全帖 |
|
l********n
发帖数: 260 | 39 Genetic Expression Profile During Acute Cellular Rejection in Clinical
Intestinal Transplantation
Bradley, Sean P.; Banner, Barbara; Elias, George; Pahari, Mohan P.; Brown,
Melissa; Rastellini, Cristiana; Cicalese, Luca
Transplantation. 86(7):998-1001, October 15, 2008.
doi: 10.1097/TP.0b013e3181874989
please send paper to a*************[email protected] |
|
l********n
发帖数: 260 | 40 Plasma MicroRNA, a Potential Biomarker for Acute Rejection After Liver
Transplantation
Hu, Jie; Wang, Zheng; Tan, Chang-Jun; Liao, Bo-Yi; Zhang, Xin; Xu, Min; Dai,
Zhi; Qiu, Shuang-Jian; Huang, Xiao-Wu; Sun, Jian; Sun, Qi-Man; He, Yi-Feng;
Song, Kang; Pan, Qi; Wu, Ying; Fan, Jia; Zhou, Jian
Transplantation. 95(8):991-999, April 27, 2013.
doi: 10.1097/TP.0b013e31828618d8
please send to email at
a*************[email protected] |
|
w*****s
发帖数: 230 | 41 附件是主治大夫的reasoning(email回复，红字)， 他的水平我们还是很佩服的，因为
他已开始猜了个病就和我们宝宝症状非常一致，可惜后来发现不是；而且他不是代谢病
专家。
问题是坚持宝宝不吃长链脂肪酸的奶粉后，他奇迹般地改善了；完全出乎医生们的预料
。我感觉医生列的是常见的代谢病，而我们感觉宝宝吃长链脂肪酸似乎是慢性中毒，大
概需要一个月左右才能体现出来。因为过程很慢，我们怀疑很多方法查不出来。
我们最大的问题是如果是这种病怎么查？不能确认的话他一辈子吃饭都受影响，基本也
就很难出门时间长一点了。尤其是他的肝已经在要换的边缘。医生们现在改口说他的病
程都是偶然，可我们不能同意。为什么每次都是长链吃一段时间就得病，尤其是这次停
了鸡蛋后马上改善。。
谢谢大家。 （下面是文字，可惜设置不成红色）
Q: Our biggest concern is the reason of his liver damage.
A: The biopsy shows severe fibrotic changes and tells us that this is not a
liver that ... 阅读全帖 |
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t******1
发帖数: 1263 | 42 fecal transplant is very popular, i once was in the main lab that does this.
Vancomycin and fragil are not very effective on some of the c.diff infected
patients. Fecal transplant has cured a lot of patients! |
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o******n
发帖数: 511 | 43 microbiome没那么玄，但也没那么不堪。我个人觉得只有gut microbiome和疾病/免疫
有很大的关系，但我不喜欢一股脑都往那上头扯，至于身体其它部位的microbiome那多
半是exploratory性质的，忽悠居多。
提到probiotics，其实市售的probiotics很多都不纯，一是时间长了有污染，也因为没
人仔细检查菌源，而很多厂的菌源来自一个地方。另外probiotics不是commensal
bacteria，只是过客而已，所以得不停吃。
用fecal transplant的确可以治c. diff，就是用健康人的菌群把c. diff给竞争死了，
但我不确定那些菌群在病人体内能不能扎根，听说有的人要接受不止一次fecal
transplant治疗。 |
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s******y
发帖数: 28562 | 44
大致看了一下，数据很有意思啊。是否暗示了Kaposi's sarcoma, non-Hodgkin's
lymphomas, and nonmelanoma skin cancers是用免疫法治疗最有前途的几种癌症？
For most common tumors, e.g. colon, lung, prostate, stomach, esophagus,
pancreas, ovary and breast, cancer rates were roughly twofold higher after
kidney transplantation compared with the general population. Melanoma,
leukemia, hepatobiliary tumors, cervical and vulvovaginal tumors were each
approximately fivefold more common. Testicular and bladder cancers were
increased approximately t... 阅读全帖 |
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G*******a
发帖数: 414 | 45 不一定。
首先，除了kidney，还有其他transplantation，不知道是否也有肿瘤增加。
第二，不知道肿瘤增加是否跟免疫抑制有关。还是跟transplant的供体年龄是否有关等
等。
第三，这几种肿瘤确实可能跟免疫有关。在HIV病人中，好像也是这几种肿瘤比较常见
？但是其他肿瘤不知道跟免疫关系有多大？
15-
nonmelanoma |
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t****w
发帖数: 130 | 46 你说得有道理 leakage也是lineage tracing的一个大问题，另外promoter activity-
driven的标记方法和实际mRNA/蛋白表达水平的差异也是个问题。虽然目前lineage
tracing被广泛运用，但我个人是非常反对把lineage tracing做为“金标准”的。
关于干细胞的研究，比lineage tracing更说明问题的应该是transplant之后系统的重
建。例如要证明细胞是ESC，最关键的标准不是Nanog等几个marker的表达，而应该看是
否细胞注入blastocyst之后能发育成chimeric mouse； 同理，证明hematopoietic
stem cell的关键在于是否能通过serial transplantation 来repopulate blood
system.类似的目前在gut,lung和skini等里边干细胞也都移植重建成功了。这在理论上
意义还是很重大的。 |
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l****y
发帖数: 486 | 47 To study HSC, usually you need to distinguish whether it is cell autonomous
(resulting from HSC defects) or cell non-autonomous effect(resulting from
microenvironment or niche defects). This can be addressed through
transplantation assay. If your transplantation assay indeed shows cell
autonomous effect, then probably you need to purify HSCs to further study
them (RNAseq etc as you mentioned below). |
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l********n
发帖数: 260 | 48 Rank full journal title Total Cites IF
1 ca-a cancer journal for clinicians 18,594 115.84
2 new england journal of medicine 268,652 55.873
4 lancet 185,361 45.217
6 nature biotechnology 45,986 41.514
7 nature 617,363 41.456
12 nature materials 64,622 36.503
13 jama-journal of the american medical association 126,479 35.289
14 nature reviews immunology 28,938 34.985
15 nature nanotechnology 34,387 34.048
16 ... 阅读全帖 |
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